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Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl) piperazines

机译：在II型糖尿病大鼠模型中，对葡萄糖稳态具有活性的咪唑啉衍生物的设计与合成。 1. N-烯基-N'-（芳基烷基）-2-（4'，5'-二氢-1'H-咪唑-2'-基）哌嗪的合成及生物活性

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Rondu, Frédéric; Le Bihan, Gaëlle; Wang, Xuan; Lamouri, Aazdine; Touboul, Estéra; Dive, Georges; Bellashene, Tounès; Pfeiffer, Bruno; Renard, Pierre; Guardiola-Lemaitre, Béatrice; Manechez, Dominique; Penicaud, Luc; Ktorza, Alain; Godfroid, Jean-Jacques;
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1. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazin [J] . Le Bihan-G, Rondu F, Pele Tounian-A, Journal of Medicinal Chemistry . 1999,第9期

机译：在II型糖尿病大鼠模型中对葡萄糖稳态具有活性的咪唑啉衍生物的设计与合成。 2. 1,4-二烷基-，1,4-二苄基和1-苄基-4-烷基-2-（4'，5'-二氢-1'H-咪唑-2'-基的合成和生物学活性哌嗪
2. Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes. [J] . Crane L, Anastassiadou M, El Hage S, Bioorganic and medicinal chemistry . 2006,第22期

机译：在2型糖尿病大鼠模型中具有高效降血糖活性的新型咪唑啉衍生物的设计与合成。
3. Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes. [J] . Crane L, Anastassiadou M, El Hage S, Bioorganic and Medicinal Chemistry . 2006,第22期

机译：在2型糖尿病大鼠模型中具有高效降血糖活性的新型咪唑啉衍生物的设计与合成。
4. Design, Synthesis and Biological Activity Study of Novel 2-(Pyrazol-5-yl)-2,3-dihydro-4(1H)-quinazolinone Derivatives [C] . Huibin Yang, Yunbo Cong, Haibo Yu, Proceedings of 4th international symposium on pesticides and environmental safety amp; 5th pan Pacific confernce on pesticide science amp; 8th international workshop on crop protection chemistry and regulatory harmonization . 2012

机译：新型2-（吡唑-5-基）-2,3-二氢-4（1H）-喹唑啉酮衍生物的设计，合成及生物活性研究
5. Structure-Based Drug Design in Medicinal Chemistry: I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition [D] . Lee, Minhee 2017

机译：药物化学中基于结构的药物设计：I.跨病变合成抑制剂的开发II。磺酰哌嗪衍生物对LpxH的抑制作用及其合成及生物学评价
6. Sterol 14α−Demethylase Structure-Based Design of VNI ((R)-N−(l- (24-Dichlorophenyl)-2-(1H−imidazol-1-yl)ethyl)-4-(5-phenyl-134- oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis Biological Evaluation and Crystallographic Analysis [O] . Laura Friggeri, Tatiana Y. Hargrove, Zdzislaw Wawrzak, -1

机译：基于甾醇14α-脱甲基酶结构的VNI（（R）-N-（1-（24-二氯苯基）-2-（1H-咪唑-1-基）乙基）-4-（5-苯基-1） 34- oxadiazol-2-yl）benzamide））衍生物靶向真菌感染：合成生物学评估和晶体学分析
7. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes.2. Syntheses and biological activities of 1,4-dialkyl-,1,4-dibenzyl and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1' H-imidazol-2'yl)piperazines and isosteric analogues of imidazoline [O] . Le Bihan, Gaëlle, Rondu, Frédéric, Pele-Tounian, Agnès, 1999

机译：具有II型糖尿病大鼠葡萄糖稳态活性的咪唑啉衍生物的设计与合成2。 1,4-二烷基-，1,4-二苄基和1-苄基-4-烷基-2-（4'，5'-二氢-1'H-咪唑-2'yl）哌嗪的合成及生物活性咪唑啉类似物

Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 1. Synthesis and biological activities of N-benyl-N'-(arylalkyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl) piperazines

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